The reason we sometimes experience prolonged itching after a mosquito bite is mainly due to our immune system’s reaction. When the mosquito’s saliva enters the skin, our body recognises it as a foreign substance. It then releases histamine, a chemical mediator involved in allergic reactions. Histamine causes blood vessels to dilate, leading to redness, swelling and, above all, that intense itching sensation.
Two types of immune response may explain the intensity and duration of the symptoms:
This occurs within minutes of the bite. It is linked to the release of histamine by certain immune cells (mast cells), which causes redness, swelling, localised warmth and intense itching. This reaction is usually temporary, but can be very uncomfortable.
This appears several hours to a few days after the sting and involves a more profound activation of the immune system (T cells). It manifests as a persistent papule, prolonged itching and, in some cases, long-lasting inflammation, particularly in children and people with atopic or allergic skin.
Other factors can prolong the discomfort
When the itching persists for several days, this can be due to various factors:
Increased individual sensitivity: Some people react more strongly to mosquito saliva, releasing more histamine or triggering a delayed reaction, which prolongs the symptoms.
Excessive scratching: The more we scratch, the more the skin becomes irritated. This perpetuates the inflammation, can damage the skin barrier and slow down healing.
The type of mosquito: Certain species, such as the tiger mosquito, inject more irritating substances or in greater quantities, causing more severe reactions.
A secondary infection: If the bite is broken or is scratched vigorously, bacteria can enter the skin, leading to persistent redness, pain or oozing.
An allergic predisposition or an exaggerated immune response: Children and people with allergies may experience reactions that last longer, are more widespread, or even result in persistent papules. In rare cases, this is referred to as "Skeeter syndrome”, an intense local allergic reaction causing marked swelling, warmth, persistent itching and, occasionally, a mild fever.
The location of the bite: Areas where the skin is thinner or has a higher density of nerve endings (wrists, ankles, face) are often more sensitive and react more strongly.
It is therefore important to quickly soothe stings that are very itchy in order to limit irritation and prevent complications.