Aroma-Zone Glabridine Active Ingredient

INCI Name: Glycyrrhiza Glabra Root Extract

VEGAN

METHOD OF EXTRACTION

Glabridin is obtained by oleo-eco-extraction from the root of liquorice.

BIOCHEMICAL COMPOSITION

Glabridine is a flavonoid belonging to the family of polyphenols, known for their antioxidant properties and their protective effects against oxidative stress.

SUSTAINABILITY / TRACEABILITY

100% naturally derived active ingredient

Glabridin is a naturally derived active ingredient extracted from liquorice root (Glycyrrhiza glabra), recognised for its targeted action on the mechanisms of skin pigmentation.

It works by inhibiting the activity of tyrosinase, a key enzyme involved in the production of melanin. By binding to its active site, it helps to limit the formation of new pigments and reduce the appearance of existing dark spots.

Its action also extends to the regulation of cellular signals involved in pigmentation. Glabridin plays a key role in reducing the activity of endothelin-1 in keratinocytes, a mediator that stimulates the proliferation and differentiation of melanocytes.

By acting at several stages of the pigmentation process, it helps to reduce the intensity of dark spots and improve skin evenness.

Furthermore, Glabridine possesses antioxidant properties, which help to neutralise the free radicals involved in oxidative stress and skin ageing. It also exhibits anti-inflammatory activity, which helps to soothe redness and limit post-inflammatory hyperpigmentation.

A Note from Adeline Nalin, Head Pharmacist and Toxicologist at Aroma-Zone

“Glabridin, the main flavonoid in Glycyrrhiza glabra, is well tolerated by the skin at the concentrations used in cosmetics. The available data do not indicate any significant irritant or sensitising effects, although mild, temporary reactions (erythema, tingling) may occur in reactive skin or where the skin barrier is compromised. These observations are consistent with the conclusions of the CIR Expert Panel (2008), which considers liquorice extracts to be safe under normal conditions of cosmetic use.”

Adeline Nalin - Head Pharmacist and Toxicologist

A Note from Our Aroma-Zone Toxicologist

“Glabridin is considered safe for health when used at the recommended concentrations in cosmetic products. The CIR, in its 2008 report, and the EFSA (European Food Safety Authority), in its 2011 scientific opinion on the food ingredient Glavonoide® (an extract enriched with glabridin), confirm the absence of any toxicological concerns at the assessed exposure levels, reinforcing confidence in the safety of this active ingredient. Our Vitamin C & Glabridine Anti-Dark Spot Oil Serum has been tested in vitro on 3D reconstructed human epidermis and has been shown to have no irritant potential (with no cytotoxicity and no expression of inflammatory markers).”

Adeline Nalin – Head Pharmacist and Toxicologist

A Note from the Dermatologist

“Glabridin is a naturally derived active ingredient sourced from liquorice root, recognised for its effect on pigmentation spots. It works in particular by inhibiting the activity of tyrosinase, a key enzyme in melanin synthesis, thereby helping to reduce pigmentation spots and improve skin evenness.

It also possesses antioxidant properties, which help to neutralise the free radicals involved in skin ageing, thereby helping to preserve the skin’s condition over time.

To maximise its effectiveness, daily application of sun protection is essential to limit stimulation of melanocytes and prevent the appearance of new dark spots.

Glabridin can be combined with other complementary active ingredients. For example, Vitamin C can be used in the morning to enhance the antioxidant and skin-evening effects, whilst active ingredients such as AHAs or retinol can be incorporated into your evening routine to promote cell renewal.”

Dr Aoun – Dermatologist

Glabridin is an active ingredient extracted from liquorice root, recognised for its targeted action on melanogenesis. 

Its fat-soluble nature makes it easy to incorporate into oily or emulsified formulations, such as oil-based serums or creams, whilst ensuring good affinity with the skin. This characteristic enables the development of skincare products that are both effective and sensorial, suitable for daily use.

Skin prone to pigmentation spots, dull and uneven skin, sensitive skin prone to redness, mature skin.

Pigment spots (brown spots, sun- or age-related spots), uneven complexion, lack of radiance, redness and post-inflammatory marks, oxidative stress and skin ageing.

• Reduces pigmentation spots

• Evens out and brightens the skin

• Protects the skin from oxidative stress

• Soothes redness and inflammation

• Improves the skin’s evenness.

Vitamin C & Glabridine Anti-Dark Spot Hand Cream

Particularly exposed to the sun and environmental stressors, the hands are an area prone to the appearance of pigmentation spots.

This certified organic hand cream combines Glabridine and Vitamin C to target pigmentation irregularities and restore the skin’s radiance. Glabridine helps to reduce dark spots by targeting melanin production, whilst Vitamin C provides a protective antioxidant effect. Enriched with hyaluronic acid, it provides long-lasting hydration without leaving a greasy residue and improves the skin’s comfort on a daily basis.

Vitamin C & Glabridine Anti-Dark Spot Oil Serum

This oil-based serum combines Glabridin with Vitamin C and Astaxanthin to deliver a comprehensive effect on pigmentation spots and the skin’s radiance. Glabridin targets the mechanisms of melanin production, whilst Vitamin C and Astaxanthin provide complementary antioxidant action, helping to protect the skin from oxidative stress linked to the appearance of dark spots.

Its fine, silky oil texture nourishes the skin without leaving a greasy film and fits easily into different skincare routines. Used on its own or alongside a serum, it helps to improve skin evenness and reveal a more radiant complexion.

Avoid contact with the eyes. In case of contact, rinse immediately with clean water.

Marion is a Doctor of Pharmacy, naturopath, and coach. After twelve years working in the cosmetics industry, she now supports her clients in achieving greater overall balance and adopting a more mindful lifestyle, with a particular focus on sustainable nutrition. She is also the creator of a podcast, where she shares her insights to promote a lifestyle philosophy that respects both health and the environment.