Aroma-Zone Vitamin B12 Active Ingredient

INCI Name: Cyanocobalamin

VEGAN

BIOCHEMICAL COMPOSITION

Vitamin B12, or cyanocobalamin, belongs to the cobalamin family, a group of water-soluble vitamins characterized by the presence of a cobalt atom at the center of their molecular structure.

Vitamin B12 is known for its soothing properties. It plays a role in regulating certain skin inflammatory mechanisms. It helps limit the production of inflammatory mediators and modulate the release of histamine, a molecule involved in skin reactions such as itching, redness, or feelings of discomfort. 

These properties explain its value in skincare products for sensitive, reactive, or atopic skin, where it helps reduce feelings of skin discomfort, itching, tingling, or tightness, and to reduce the appearance of redness.

A Note from Adeline Nalin, Head Pharmacist and Toxicologist at Aroma-Zone

“Vitamin B12, or cyanocobalamin, is an essential vitamin for the human body, with recommended daily intakes of approximately 2 to 4 µg per day for adults (EFSA). It is a large molecule (molecular weight > 1,000 Da), which significantly limits its ability to cross the skin barrier and results in negligible percutaneous penetration. 

In cosmetic products, Vitamin B12 is used at very low concentrations and exhibits excellent skin tolerance at these levels. Available data indicate that it is neither irritating nor toxic to the skin under normal conditions of use. 

Cases of hypersensitivity or allergy have been reported in the scientific literature, primarily in medical contexts (parenteral administration, high doses) or following exposure to concentrations far higher than those found in cosmetics. These adverse effects are not considered relevant for standard topical cosmetic use. 

A slight, temporary pinkish discoloration of the skin may occasionally be observed after application. This effect is reversible, has no clinical consequences, and disappears spontaneously.”

Adeline Nalin - Head Pharmacist and Toxicologist

A Note from Our Aroma-Zone Toxicologist

"Vitamin B12 is widely used in cosmetics and has a favourable safety profile, offering real benefits for the skin, particularly in formulations designed for sensitive or fragile skin. At the concentrations used in cosmetic products, cyanocobalamin is non-irritating and non-sensitising for the vast majority of users.

However, as with any ingredient, rare cases of allergic contact dermatitis have been reported in the literature, generally linked to exposure to high concentrations or in individuals with a particular predisposition to allergies. As a precaution, for individuals with a history of skin reactions to vitamins or very reactive skin, it is recommended to perform a patch test in the inner elbow 48 hours before widespread use."

Adeline Nalin - Head Pharmacist and Toxicologist

A note from the Dermatologist

“Vitamin B12, or cyanocobalamin, is a relatively new active ingredient in cosmetology, renowned for its soothing properties, making it an ideal ingredient for the care of sensitive or reactive skin.”

Dr. Reyhan Amode

The Vitamin B12 has an interesting characteristic in cosmetic formulations: its naturally pink color, which stems from its chemical structure containing a cobalt atom. When incorporated into a formula, it can thus impart a pinkish tint to the finished product without the need to add colorants.

All skin types, particularly sensitive, reactive, or weakened skin, as well as dry to very dry skin prone to redness and discomfort.

Diffuse redness, tightness, tingling, itching, dry skin, discomfort in sensitive or reactive skin, compromised skin barrier.

• Soothe discomfort

• Reduce the appearance of redness

• Promote comfort in sensitive skin

• Maintain the skin barrier.

Concentrated Vitamin B12 & Prebiotics Serum

To enjoy the benefits of Vitamin B12, discover our Vitamin B12 & Prebiotics Concentrated Serum. Specially formulated for sensitive and reactive skin, this serum combines Vitamin B12, Prebiotics, and Ceramides NP to quickly soothe discomfort, reduce redness, and support the skin barrier. The skin regains comfort and balance, immediately and long-lasting.

Marion is a Doctor of Pharmacy, naturopath, and coach. After twelve years working in the cosmetics industry, she now supports her clients in achieving greater overall balance and adopting a more mindful lifestyle, with a particular focus on sustainable nutrition. She is also the creator of a podcast, where she shares her insights to promote a lifestyle philosophy that respects both health and the environment.