Comprehensive In & Out* Anti-Dryness Routine – 4 steps

1. Plum & Oat Cleansing Oil: morning and/or evening on dry skin, apply using circular massaging movements, add a little water and massage again, then rinse with clean water.

2. 3.5% Hyaluronic Acid Concentrated Serum: morning and evening, apply a few drops to the face and neck before the Lipid-Restoring Balm.

3. Oat & Ceramide NP Lipid-Restoring Balm: Apply to the entire face and neck in the morning and evening.

4. Hyaluronic Acid – 60 capsules – Dietary supplement: take 1 capsule a day with a large glass of water.

Plum & Oat Cleansing Oil

This make-up remover oil gently cleanses dry skin, while respecting the hydrolipidic film and preserving the skin’s natural moisture.

Discover the Plum & Oat Cleansing Oil.

3.5% Hyaluronic Acid Concentrated Serum

Thanks to its 3.5% concentration of hyaluronic acid – one of the highest on the market – this serum attracts and retains water in the upper layers of the skin for intense hydration.

Discover the 3.5% Concentrated Hyaluronic Acid Serum.

Oat & Ceramide NP Lipid-Restoring Balm

Its nourishing, lipid-replenishing complex strengthens the skin barrier, nourishing and protecting the skin from external damage for immediate comfort.

Discover the Oat & Ceramide NP Lipid-Restoring Balm.

Hyaluronic acid – Dietary supplement

This supplement provides 150 mg of sodium hyaluronate per capsule, in a high-purity form obtained through biofermentation, to help maintain the skin’s moisture levels from within.

Discover Hyaluronic Acid – Dietary supplement.

Hyaluronic acid – 60 capsules – Dietary supplement: provides 150 mg of sodium hyaluronate per capsule, in a high-purity form obtained through biofermentation.

Plum & Oat Cleansing Oil

• 100%: effectively removes make-up¹

• 91%: effectively removes waterproof make-up¹

• 100%: gently and effectively cleanses the skin¹

• 95%: removes impurities and leaves the skin clear¹

• 100%: skin feels nourished, soft and comfortable after use¹

• 95%: reduces tightness¹

• 95%: visibly smooths the skin’s texture¹

• 91%: skin is visibly more radiant¹

• 100%: effectively removes sun protection¹

• 100%: preserves the skin’s hydrolipidic film¹

¹ % satisfaction rate, test carried out in a laboratory under dermatological and ophthalmological supervision over 28 days on a panel of 22 volunteers, 50% of whom had sensitive skin.

3.5% Hyaluronic Acid Concentrated Serum

Intense, long-lasting hydration for up to 6 hours after application²

• 80%: firms the facial contours³

• 80%: improves skin elasticity³

• 80%: smooths the skin³

• 85%: skin appears radiant and luminous³

• 80%: the skin is revitalised³

• 80%: long-lasting moisturising effect³

² Test carried out in a laboratory using the corneometry method.

³ % satisfaction rate, test carried out in a laboratory under dermatological supervision over 28 days on a panel of 20 volunteers, 10 of whom had sensitive skin.

Oat & Ceramide NP Lipid-Restoring Balm

Immediate soothing

• 86%: reduces irritation and itching⁴

• 91%: soothes redness and reduces tightness⁴

• 95%: skin soothed⁴

Long-lasting comfort

• 95%: skin feels soft and moisturised⁴

• 95%: skin feels less rough⁴

• 86%: immediate comfort⁴

• 91%: skin feels soothed and softened⁴

Repairs the skin and prevents recurrence

• 91%: leaves a protective film on the skin⁴

• 95%: protects and strengthens the skin barrier⁴

• 95%: reduces skin dryness⁴

• 95%: repairs and nourishes the skin⁴

⁴ % satisfaction rate, based on laboratory tests carried out under dermatological supervision over 28 days on a total of 22 people with sensitive skin, 20% of whom had skin prone to atopic conditions, dry or very dry skin.

Storage

Plum & Oat Cleansing Oil: Store at room temperature and away from heat. The PAO (Period After Opening) for this product is 12 months. The make-up remover oil may become cloudy in cold weather; this does not affect its quality or properties in any way. Simply leave it at room temperature and it will become clear again.

3.5% Hyaluronic Acid Concentrated Serum: Base on its own: The PAO (Period After Opening) for this product is 9 months. Personalised base: If stored correctly away from heat and light and manufactured under optimal hygienic conditions, your product will keep for 3 months.

Oat & Ceramide NP Lipid-Restoring Balm: Store away from heat. Personalised base: If stored correctly away from heat and light and manufactured under optimal hygienic conditions, your product will keep for 3 months.

Hyaluronic Acid – 60 capsules – Food supplement: Store away from light, heat and moisture, in the tightly sealed jar.

Precautions

Plum & Oat Make-up Remover Oil: If you personalise your make-up remover oil with essential oils and fragrances, we recommend using your personalised oil only on the face, avoiding contact with the eyes. In case of contact, rinse with clean water. Personalisation is recommended for adults only.

3.5% Hyaluronic Acid Concentrated Serum: Avoid contact with the eyes; in case of contact, rinse immediately and thoroughly with clean water. Personalisation is recommended for adults only.

Oat & Ceramide NP Lipid-Restoring Balm: The PAO (Period After Opening) for this product is 9 months. Apply to healthy skin. Do not apply to severely irritated or damaged skin or to weeping lesions. Personalisation is recommended for adults only.

Hyaluronic Acid – 60 capsules – Food supplement: Keep out of reach of children. Not a substitute for a varied and balanced diet and a healthy lifestyle. Do not exceed the recommended daily dose. For adults only. Not recommended for pregnant or breastfeeding women.

Responsible Person

• EU responsible person: Aroma-Zone FR-84220 Cabrières d’Avignon

• UK responsible person: Obelis UK Ltd, Sandford Gate, Oxford, OX4 6LB, UK

Skin barrier & dry skin

[1] Proksch E, Brandner JM, Jensen JM. “The skin: an indispensable barrier.” Exp Dermatol. 2008;17(12):1063–72. → A key reference on skin barrier function, the PIE and the lipid composition of the stratum corneum.

[2] Van Smeden J, Janssens M, Gooris GS, Bouwstra JA. "The important role of stratum corneum lipids for the cutaneous barrier function." Biochim Biophys Acta. 2014;1841(3):295–313. → Confirms the central role of lipids (including ceramides) in the cohesion of the stratum corneum and water retention.

[3] Darlenski R, Fluhr JW. "Influence of skin type, wetness, age, sex, pH, and temperature on skin barrier function." Skin Pharmacol Physiol. 2012;25(2):55–62. → Quantifies the impact of PIE according to skin type — supports the clinical rationale for the routine.

NP Ceramides

[4] Coderch L, López O, de la Maza A, Parra JL. "Ceramides and skin function." Am J Clin Dermatol. 2003;4(2):107–29. → A landmark review on the role of ceramides in barrier function: they constitute 40 per cent of the lipids in the stratum corneum.

[5] Meckfessel MH, Brandt S. "The structure, function, and importance of ceramides in skin and their use as therapeutic agents in skin-care products." J Am Acad Dermatol. 2014;71(1):177–84. → Justifies the topical use of exogenous ceramides to restore the skin barrier in dry skin — directly applicable to NP Balm

[6] Thakoersing VS, et al. “Increased presence of monounsaturated fatty acids in the stratum corneum of human skin equivalents.” J Invest Dermatol. 2012;132(3 Pt 2):S104. → Link between fatty acid deficiency and barrier impairment — the scientific basis for the relipidising approach.

Topical hyaluronic acid

[7] Papakonstantinou E, Roth M, Karakiulakis G. “Hyaluronic acid: A key molecule in skin ageing.” Dermatoendocrinol. 2012;4(3):253–8. → Explains the role of hyaluronic acid in water retention and skin elasticity.

[8] Bukhari SNE et al. "Hyaluronic acid, a promising skin rejuvenating biomedicine: A review of recent updates." Int J Biol Macromol. 2018;120(Pt B):1682–1695. → A recent review of the different molecular sizes of hyaluronic acid and their complementary effects on the skin’s surface.

Oats (Avena sativa)

[9] Kurtz ES, Wallo W. “Colloidal oatmeal: history, chemistry and clinical properties.” J Drugs Dermatol. 2007;6(2):167–70. → The soothing, anti-pruritic and protective properties of colloidal oats — directly linked to the Balm and the Make-up Remover Oil.

[10] Pazyar N, Yaghoobi R, et al. "Oat in dermatology: a brief review." Indian J Dermatol Venereol Leprol. 2012;78(2):142–5. → Confirms the clinical use of oat extract for dry, atopic and irritated skin.

Gascony Plum Oil & Omega-9

[11] Savic I, Savic Gajic I, Gajic D. “Physico-Chemical Properties and Oxidative Stability of Fixed Oil from Plum Seeds (Prunus domestica Linn.).” Biomolecules. 2020;10(2):294. → Characterisation of plum oil: high in oleic acid (omega-9) and tocopherols, with good oxidative stability — supports all product claims.

Omega-3 and the skin

[12] McCusker MM, Grant-Kels JM. “Healing fats of the skin: the structural and immunological roles of omega-6 and omega-3 fatty acids.” Clin Dermatol. 2010;28(4):440–51. → Role of AGEs (omega-3 and 6) in membrane composition and the hydrolipid film — supports Dr Espinasse’s argument without constituting a product claim.

Stress, sleep and skin barrier function:

Maarouf, M et al. “The impact of stress on epidermal barrier function: an evidence-based review.” The British Journal of Dermatology vol. 181,6 (2019): 1129–1137. doi:10.1111/bjd.17605

Gut-skin axis:

Mahmud MR, Akter S, Tamanna SK, Mazumder L, Esti IZ, Banerjee S, Akter S, Hasan MR, Acharjee M, Hossain MS, Pirttilä AM. Impact of the gut microbiome on skin health: the gut-skin axis viewed through the lens of therapeutics and skin diseases. Gut Microbes. 2022 Jan–Dec;14(1):2096995. doi: 10.1080/19490976.2022.2096995. PMID: 35866234; PMCID: PMC9311318.

-Proksch E, Jensen JM, Elias PM. Skin lipids and epidermal differentiation in atopic dermatitis. Clin Dermatol. 2003 Mar–Apr;21(2):134–44. doi: 10.1016/s0738-081x(02)00370-x. PMID: 12706331.

-Fujii M. The Pathogenic and Therapeutic Implications of Ceramide Abnormalities in Atopic Dermatitis. Cells. 10 September 2021;10(9):2386. doi: 10.3390/cells10092386. PMID: 34572035; PMCID: PMC8468445.

-Meckfessel MH, Brandt S. The structure, function, and importance of ceramides in the skin and their use as therapeutic agents in skincare products. J Am Acad Dermatol. July 2014;71(1):177–84. doi: 10.1016/j.jaad.2014.01.891. Epub 20 March 2014. PMID: 24656726.