Anti-Dryness Duo – 2-step

1. 3.5% Hyaluronic Acid Concentrated Serum: apply a few drops to the face and neck, morning and/or evening, before the Lipid-Restoring Balm.

2. Oat & Ceramide NP Lipid-Restoring Balm: apply morning and evening all over the face and neck to lock in moisture.

3.5% Concentrated Hyaluronic Acid Serum

Formulated with a very high concentration of hyaluronic acid of varying molecular weights, this serum attracts and retains water in the upper layers of the skin.

Discover the 3.5% Concentrated Hyaluronic Acid Serum

Oat & Ceramide NP Lipid-Restoring Balm

Its texture, rich in Ceramide NP and plant-based oils, helps to compensate for the lack of natural oils typically found in dry skin, providing immediate comfort.

Discover the Oat & Ceramide NP Lipid-Restoring Balm

3.5% Hyaluronic Acid Concentrated Serum

Intense, long-lasting hydration for up to 6 hours after application¹

• 80%: firms the facial contours²

• 80%: improves skin elasticity²

• 80%: smooths the skin²

• 85%: skin appears radiant and luminous²

• 80%: the skin is revitalised²

• 80%: the skin is long-lasting moisturised²

¹ Test carried out in a laboratory using the corneometry method.

² % satisfaction rate, test carried out in a laboratory under dermatological supervision over 28 days on a panel of 20 volunteers, 10 of whom had sensitive skin.

Oat & Ceramide NP Lipid-Restoring Balm

• 86%: reduces irritation and itching³

• 91%: soothes redness and reduces tightness³

• 95%: soothed skin³

• 95%: skin feels soft and moisturised³

• 95%: less rough skin³

• 86%: immediate comfort³

• 91%: skin feels relieved and softened³

• 91%: leaves a protective film on the skin³

• 95%: protects and strengthens the skin barrier³

• 95%: reduces skin dryness³

• 95%: repairs and nourishes the skin³

³ % satisfaction rate, based on laboratory tests carried out under dermatological supervision over 28 days on a total of 22 people with sensitive skin, 20% of whom had skin prone to atopic conditions, dry or very dry skin.

Storage

3.5% Hyaluronic Acid Concentrated Serum: Base product alone: The PAO (Period After Opening) for this product is 9 months. Personalised base: If stored away from heat and light and made under optimal hygienic conditions, your product will keep for 3 months.

Oat & Ceramide NP Lipid-Restoring Balm: Store away from heat. Personalised base: If stored correctly away from heat and light and manufactured under optimal hygienic conditions, your product will keep for 3 months.

Precautions

3.5% Concentrated Hyaluronic Acid Serum: Avoid contact with the eyes; in case of contact, rinse immediately and thoroughly with clean water. Personalisation is recommended for adults only.

Oat & Ceramide NP Lipid-Restoring Balm: The PAO (Period After Opening) for this product is 9 months. Apply to healthy skin. Do not apply to severely irritated or damaged skin or to weeping lesions. Personalisation is recommended for adults only.

Responsible Person

• EU responsible person: Aroma-Zone FR-84220 Cabrières d’Avignon

• UK responsible person: Obelis UK Ltd, Sandford Gate, Oxford, OX4 6LB, UK

Skin barrier & dry skin

[1] Proksch E, Brandner JM, Jensen JM. "The skin: an indispensable barrier."

Exp Dermatol. 2008;17(12):1063–72. → Key reference on skin barrier function, the PIE and the lipid composition of the stratum corneum.

[2] Van Smeden J, Janssens M, Gooris GS, Bouwstra JA. "The important role of stratum corneum lipids for the cutaneous barrier function."

Biochim Biophys Acta. 2014;1841(3):295–313. → Confirms the central role of lipids (including ceramides) in the cohesion of the stratum corneum and water retention.

[3] Darlenski R, Fluhr JW. "Influence of skin type, wetness, age, sex, pH, and temperature on skin barrier function."

Skin Pharmacol Physiol. 2012;25(2):55–62. → Quantifies the impact of PIE according to skin type — supports the clinical rationale for the routine.

NP ceramides

[4] Coderch L, López O, de la Maza A, Parra JL. "Ceramides and skin function."

Am J Clin Dermatol. 2003;4(2):107–29. → A landmark review on the role of ceramides in barrier function: they constitute 40 per cent of the lipids in the stratum corneum.

[5] Meckfessel MH, Brandt S. "The structure, function, and importance of ceramides in skin and their use as therapeutic agents in skin-care products."

J Am Acad Dermatol. 2014;71(1):177–84. → Justifies the topical use of exogenous ceramides to restore the skin barrier in dry skin — directly applicable to NP Balm.

[6] Thakoersing VS, et al. "Increased presence of monounsaturated fatty acids in the stratum corneum of human skin equivalents."

J Invest Dermatol. 2012;132(3 Pt 2):S104. → Link between fatty acid deficiency and barrier impairment — the scientific basis for the relipidising approach.

Topical hyaluronic acid

[7] Papakonstantinou E, Roth M, Karakiulakis G. "Hyaluronic acid: A key molecule in skin ageing."

Dermatoendocrinol. 2012;4(3):253–8. → Explains the role of hyaluronic acid in water retention and skin elasticity.

[8] Bukhari SNE et al. "Hyaluronic acid, a promising skin rejuvenating biomedicine: A review of recent updates."

Int J Biol Macromol. 2018;120(Pt B):1682–1695. → A recent review of the different molecular sizes of HA and their complementary effects on the skin’s surface.

Oats (Avena sativa)

[9] Kurtz ES, Wallo W. "Colloidal oatmeal: history, chemistry and clinical properties."

J Drugs Dermatol. 2007;6(2):167–70. → The soothing, anti-pruritic and protective properties of colloidal oats — directly linked to the Balm and Make-up Remover Oil.

[10] Pazyar N, Yaghoobi R, et al. "Oat in dermatology: a brief review."

Indian J Dermatol Venereol Leprol. 2012;78(2):142–5. → Confirms the clinical use of oat extract for dry, atopic and irritated skin.

Gascony Plum Oil & Omega-9

[11] Savic I, Savic Gajic I, Gajic D. "Physico-Chemical Properties and Oxidative Stability of Fixed Oil from Plum Seeds (Prunus domestica Linn.)."

Biomolecules. 2020;10(2):294. → Characterisation of plum oil: high in oleic acid (omega-9) and tocopherols, with good oxidative stability — supports all product claims.

Omega-3 and the skin

[12] McCusker MM, Grant-Kels JM. “Healing fats of the skin: the structural and immunological roles of omega-6 and omega-3 fatty acids.”

Clin Dermatol. 2010;28(4):440–51. → Role of AGEs (omega-3 and 6) in membrane composition and the hydrolipid film — supports Dr Espinasse’s argument without constituting a product claim.

Stress, sleep and skin barrier function:

Maarouf, M et al. “The impact of stress on epidermal barrier function: an evidence-based review.” The British Journal of Dermatology vol. 181,6 (2019): 1129–1137. doi:10.1111/bjd.17605

Gut-skin axis:

Mahmud MR, Akter S, Tamanna SK, Mazumder L, Esti IZ, Banerjee S, Akter S, Hasan MR, Acharjee M, Hossain MS, Pirttilä AM. Impact of the gut microbiome on skin health: the gut-skin axis observed through the lenses of therapeutics and skin diseases. Gut Microbes. 2022 Jan–Dec;14(1):2096995. doi: 10.1080/19490976.2022.2096995. PMID: 35866234; PMCID: PMC9311318.

-Proksch E, Jensen JM, Elias PM. Skin lipids and epidermal differentiation in atopic dermatitis. Clin Dermatol. 2003 Mar–Apr;21(2):134–44. doi: 10.1016/s0738-081x(02)00370-x. PMID: 12706331.

-Fujii M. The Pathogenic and Therapeutic Implications of Ceramide Abnormalities in Atopic Dermatitis. Cells. 10 September 2021;10(9):2386. doi: 10.3390/cells10092386. PMID: 34572035; PMCID: PMC8468445.

-Meckfessel MH, Brandt S. The structure, function, and importance of ceramides in the skin and their use as therapeutic agents in skincare products. J Am Acad Dermatol. July 2014;71(1):177–84. doi: 10.1016/j.jaad.2014.01.891. Epub 20 March 2014. PMID: 24656726.