The hypothalamus regulates body temperature around a set point. The precise value of this set point follows a circadian rhythm and can also rise with trauma and sepsis.
In thermoregulation, the body is regarded as having a ‘central’ compartment containing the heat-producing organs, surrounded by a cooler ‘shell’ consisting of the skin and subcutaneous tissues, particularly in the arms and legs. Heat is generated by basal metabolism, muscle contractions (shivering, voluntary activity and behaviour), food intake, and, in newborns, non-shivering thermogenesis in brown adipose tissue.
Information reaches the hypothalamus via receptors that respond to heat and cold. Heat-sensitive receptors are found mainly in the central compartment, including the spinal cord, hypothalamus, abdominal viscera and large blood vessels, whereas cold-sensitive receptors are found mainly in the skin.
Heat is retained through vasoconstriction of peripheral blood vessels, which helps create the ‘heat shell’, and is lost through conduction, convection, radiation, and perspiration.
Core temperature can be measured at various sites, including the tympanic membrane, external auditory canal, nasopharynx, oesophagus, rectum, axilla, and under the tongue. Each method has its advantages and disadvantages and yields slightly different readings.


